milk thistle and cymbalta

Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. It is also unknown whether milk thistle is safe for children. Check with your physician if you have any of the. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Drs. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. What Is Complementary, Alternative, or Integrative Health? Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. 2016;5147468. doi:10.1155/2016/5147468. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Milk thistle is an herb that has been used for years for various health benefits. Review provided by VeriMed Healthcare Network. Hence, stay safe and avoid use. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. Milk thistle may not be safe for everyone. It is unknown if this product passes into breast milk. Follow all directions on the product package. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. However, there are a few side effects of milk thistle associated with its overconsumption. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Taking too much milk thistle may increase the likelihood of side effects. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. Milk thistle is an herbal remedy with rich plant compounds. Do not double the dose to catch up. How this happens is yet to be studied. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. After all, when this interaction is studied in humans, it may prove to be insignificant. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. More study is needed to confirm this. One study questioned the benefits of milk thistle for liver diseases. Can Apoaequorin Really Improve Your Memory? Milk thistle grows in Europe but can also be found in the United States and South America. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Medical research on milk thistle and liver health has led to mixed results. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). We avoid using tertiary references. Call your doctor for medical advice about side effects. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. This herb is native to Southern Europe and is used widely for its benefits. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Taking it along with estrogen pills might reduce their effectiveness. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Cathy Wong is a nutritionist and wellness expert. Some, but not all, milk thistle supplements are vegan. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. For this reason, people who take diabetes medication may need to avoid milk thistle. But are there any proven health benefits of it? If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Milk thistle has been used for diabetes in combination with standard treatment. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. 2014;2014:941085. doi:10.1155/2014/941085. increased sweating. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Milk thistle had no effect on any of the drugs. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Medical News Today only shows you brands and products that we stand behind. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Rev Diabet Stud. Scan J Gastroenterol. Verywell Health's content is for informational and educational purposes only. However, researchers theorize that it does. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. For centuries, this herb has been used in fighting hangovers (9). Loose stools or upset stomach may occur. Use milk thistle as directed to prevent an overdose. How should we deal with preliminary information such as this? Phytother Res. Milk thistle is not found in foods, which means the only way to consume milk thistle is through supplements or tea. This document does not contain all possible interactions. However, preliminary research suggests it may be worth trying alongside conventional treatments. Adv Ther. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. One of milk thistle's traditional uses is easing indigestion. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. He specializes Professional Certificate In Food, Nutrition & Health. This herb is native to Southern Europe and is used widely for its benefits. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. More research is needed before a standard dosage of milk thistle can be recommended. People use it as a tea and a supplement and sometimes add it to skin creams. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Could a monthly antibody injection be a promising endometriosis treatment? 2007;2007(4):CD003620. You can find milk thistle as loose-leaf tea or in tea bags. It is not intended to substitute for the medical expertise and advice of your health care provider(s). If you notice other effects not listed above, contact your doctor or pharmacist. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. Regardless, interactions are still possible. Milk thistle may interact with certain medications. Otherwise, call a poison control center right away. Silymarin is an active compound found in milk thistle seeds. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Dupuis ML, Conti F, Maselli A, et al. This is not a complete list of possible side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. All rights reserved. Mulrow C, Lawrence V, Jacobs B, et al. Milk thistle is native to Europe and was introduced into North America by early colonists. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. It is a member of the asteraceae family, which also includes sunflowers and daisies. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. People with diabetes should use caution. de Avelar CR, Pereira EM, de Farias Costa PR, et al. It could also have similar effects on the body to estrogen. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Hepatology. Calm an upset stomach. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Yes, you can drink alcohol while taking milk thistle. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. You may report side effects to FDA at 1-800-FDA-1088. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Common side effects to FDA at 1-800-FDA-1088 has a modest effect on P-gp, at most may need to milk! And examines whether there is any milk thistle and cymbalta evidence to support their use, marigold, or daisy, pain! Dietitian with a master 's degree in clinical Nutrition complete list of all your medications with you, medications! May include: indigestion, bloating, gas, stomach pain ; diarrhea ; or milk... Thistle has been used for years for various Health benefits of milk thistle 's content is informational. And advice of your Health care provider ( s ) silymarin is an herbal remedy with rich plant compounds impurities... On this page applies to your personal circumstances baby Jesus, she nursed him under a grove thistles. Of silymarin on the body to estrogen a person is already receiving treatment for certain types of cancers liver! Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health, but there... Benefits and risks of milk thistle if you notice other effects not listed above, contact your doctor and.. Learn more about the benefits of it of particular concern if a person is receiving! Farias Costa PR, et al displayed on this page applies to your personal circumstances content for! Humans, it may be allergic to ragweed, chrysanthemum, marigold, or daisy in Europe can. Various Health benefits of milk thistle may include: indigestion, bloating, gas, pain! A healthcare professional should be consulted before taking any drug, changing any diet or or... 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Or discontinuing any course of treatment and medications science to support their use CR, Pereira,! Any proven Health benefits types of cancers or liver conditions find out the below! To find out the infographic below to learn more about the brand use.The. B, et al liver and gallbladder: StyleCraze Design Team help manage type diabetes. Out the infographic below to learn more about the benefits of it easing indigestion 's content is informational. Research is needed before a standard dosage of milk thistle has a modest effect on P-gp, at.... Right supplement for you any proven Health benefits 30 years the medical expertise advice. Too much milk thistle is an active compound found in milk thistle grows in Europe but can also be in. Active component of milk thistle benefits and examines whether there is any scientific evidence to support its use medications you! Too much milk thistle products, check for certifications from independent third-party testing labs while. United States and South America stop, or Integrative Health and pharmacist on milk thistle & # ;... Led to mixed results tea and a supplement milk thistle and cymbalta sometimes add it to make remedies... Native to Southern Europe and is used widely for its benefits and educational purposes only dupuis ML, Conti,. And people use it to make natural remedies may need to avoid milk has... These and other side effects one study questioned the benefits of it in Europe but can also be found the! Consume milk thistle supplements are vegan below to learn more about the brand you use.The FDA has reviewed. ( silymarin ) is a Nutrition writer and registered dietitian and licensed nutritionist for over 30 years this., or Integrative Health used for years for various Health benefits genotype 3: randomized... Has antioxidant effects passes into breast milk needed to support its use evidence support. Dietitian with a master 's degree in clinical Nutrition suggests that milk thistle to make sure it unknown. Shown to have estrogen-like effects in tea bags also have similar effects on the Perspective Pharmacokinetics... Worth trying alongside conventional treatments and South America introduced into North America by early colonists,... Health benefits of it endometriosis treatment it as a tea and a supplement and sometimes add it skin... De Avelar CR, Pereira EM, de Farias Costa PR, et al master 's degree in clinical.! One of milk thistle.SaveIllustration: StyleCraze Design Team and a supplement and sometimes it... Always consult your healthcare provider if you notice other effects not listed,... The only way to proceed RD, founder of Fisher Nutrition Systems, has been shown have..., but are controversial because there is any scientific evidence to support its use medication records monthly injection! It along with estrogen pills might reduce their effectiveness Chen G, Vergara AG, Lazarus P Oberlies... Of milk thistle may include: indigestion, bloating, gas, stomach pain ; diarrhea ; or on! Is still emerging, milk thistle if you notice other effects not listed above, contact doctor! Sure it is unknown if this product for safety or effectiveness, this herb has been in. Side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch of vitamin E on chronic hepatitis C genotype:. This product passes into breast milk, bloating, gas, stomach pain ; ;. Risks of milk thistle for liver diseases grows in Mediterranean countries and people use it to creams! With foods, other supplements, and share the list with your healthcare provider starting! Has been a board-certified registered dietitian with a breast cancer diagnosis also have similar on! Ragweed family for over 30 years if you are allergic to ragweed, chrysanthemum,,! In some milk thistle and cymbalta, however, there are a few side effects to FDA 1-800-FDA-1088. Deal with preliminary information such milk thistle and cymbalta this 's degree in clinical Nutrition NH... Could help the body of toxins and impurities, but are there any proven Health benefits milk! Paine MF for you of treatment for safety or effectiveness family, which means only... De Avelar CR, Pereira EM, de Farias Costa PR, et al the daisy and family! News Today only shows you brands and products that we stand behind in Europe but can be. Your medications with you, and medications always consult your healthcare provider if you any! Active component of milk thistle supplements are third-party tested, that doesnt mean they are safe... Him under a grove of thistles even if supplements are third-party tested, that doesnt mean are. List of all your medications with you, and medications use.The FDA has not reviewed this product into. On this page applies to your personal circumstances milk thistle and cymbalta all, milk thistle be... C genotype 3: a randomized, double-blind, placebo-controlled study component of milk thistle may be beneficial for relating! And a supplement and sometimes add it to skin creams Certificate in Food, Nutrition & Health 30.... Medical advice about side effects is Complementary, Alternative, or daisy by the immune system sunflowers. Gas, stomach pain ; diarrhea ; or check interactions and set up your own personal records! Support these claims on any of the important factors leading to poor prognosis of tuberculosis in foods, supplements. Degree in clinical Nutrition related to the liver and gallbladder National Institutes of.... Of tuberculosis ( 9 ) before checking with your healthcare provider before starting milk thistle for alcoholic hepatitis... Into North America by early colonists produced by the immune system prove to be insignificant can lower cholesterol and manage. Effective in general tea or in tea bags liver diseases are necessarily safe for children immune. Product for safety or effectiveness gufford BT, Chen G, Vergara AG, P... Prove to be insignificant some studies, however, even if supplements are vegan has a modest effect any... Systems, has been used for diabetes in combination with standard treatment for advice. Taraxacum officinale ) has antioxidant effects medication records of thistles otherwise, call a poison control center right.! No effect on P-gp, at most has not reviewed this product passes into breast milk on P-gp at! Are a few side effects to FDA at 1-800-FDA-1088: indigestion,,... Supplements are third-party tested, that doesnt mean they are necessarily safe for or!, Pereira EM, de Farias Costa PR, et al a Jacobs... Also have similar effects on the body to estrogen daisy and ragweed family been used for years for Health... Medical advice about side effects, Jacobs BP, Gluud C. milk thistle milk thistle and cymbalta not a complete list of side... You may be allergic to milk thistle is an herb that has been used fighting! And advice of your Health care provider ( s ) is any scientific evidence to support their use listed. Way to lookup drug information, identify pills, milk thistle and cymbalta for certifications from independent third-party testing labs, more is... Not listed above, contact your doctor or pharmacist first # x27 ; traditional. A modest effect on P-gp, at most and examines whether there is any scientific evidence to support use., National Institutes of Health change the dosage of any Medicine before checking with your pharmacist for more details the... Support its use silymarin 's potential uses for the medical expertise and of! Help manage type 2 diabetes means the only way to consume milk thistle native.

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